Description
INTRODUCTION ABOUT TOFE TABLET
TOFE TABLET contains Tofacitinib, which belongs to the group of medicines called Antirheumatics. It is used to manage inflammatory diseases such as rheumatoid arthritis (chronic inflammatory diseases affecting the joints, causing pain and swelling), psoriatic arthritis (an arthritic condition that occurs in an individual with psoriasis), ulcerative colitis (ulcerative inflammation of the digestive tract) and ankylosing spondylitis (fusion of bones in the spine).
TOFE TABLET is also used to manage polyarticular juvenile idiopathic arthritis and juvenile psoriatic arthritis, which cause pain and inflammation of joints in children. TOFE TABLET is used alone or together with other drugs, such as methotrexate.
TOFE TABLET is not recommended for use in patients with severe liver diseases (including cirrhosis), bloodstream infections or active tuberculosis. TOFE TABLET should be used with caution in patients who have an infection or a condition that increases their risk of infection (for example, diabetes, HIV/AIDS or a weak immune system), chronic lung disease, tuberculosis, hepatitis B or C, liver, kidney or heart diseases, cancer or are at risk of developing skin cancer, smoking habits, lactose intolerance, inflammation of the large intestine, stomach or intestine ulcers, blood pressure, high cholesterol or at risk of developing a blood clot, are planning to get vaccinated, have undergone major surgery.
TOFE TABLET should not be used by pregnant or breastfeeding women. TOFE TABLET should be used with caution in patients over the age of 65. The safety and effectiveness of TOFE TABLET in children under the age of two have not yet been established.
Lung infection, sore throat, sinusitis, vomiting, nausea, diarrhoea, indigestion and headache are the most common side effects of TOFE TABLET. Ask for your doctor’s advice if any of these worsen or don’t improve.
USES OF TOFE TABLET
Manages inflammatory conditions such as:
- rheumatoid arthritis
- psoriatic arthritis
- ulcerative colitis
- ankylosing spondylitis
- polyarticular juvenile idiopathic arthritis
- juvenile psoriatic arthritis
HOW TOFE TABLET WORKS
TOFE TABLET helps in managing inflammatory diseases by modifying the immune system. It manages the body from responding to these substances called cytokines (controls growth and activity of other immune system cells and blood cells). It also inhibits the inflammation process via a new pathway (Janus kinases).
DIRECTIONS FOR USE
Take TOFE TABLET as advised by your physician. Swallow the medicine with a glass of water. It can also be crushed and taken with water. Do not chew the medicine. Your doctor will decide the correct dose and duration of TOFE TABLET for you depending on your age, disease condition and body weight.
SIDE EFFECTS OF TOFE TABLET
COMMON
- lung infection such as pneumonia or bronchitis
- shingles (herpes zoster)
- nasopharyngitis (infections of the nose, throat or windpipe)
- influenza
- sinusitis
- urinary bladder infection
- sore throat
- signs of muscle problems
- stomach pain (possibly due to inflammation of the stomach lining)
- vomiting, nausea
- diarrhoea
- indigestion
- anaemia
- fever, fatigue
- swelling of the feet and hands
- headache
- high blood pressure
- cough
- rash
UNCOMMON
- tuberculosis
- signs of kidney problems (blood creatinine increase)
- skin infection, skin redness, itching
- cold sores (tiny painful blisters at the border of the lip)
- low white blood cells
- signs of liver problems (increase in liver enzyme,)
- increased cholesterol
- weight gain
- dehydration
- muscle strain
- pain in the muscles and joints, tendonitis (inflammation of tendons)
- joint swelling and sprain
- abnormal sensations
- poor sleep
- sinus congestion
- shortness of breath or difficulty breathing
- fatty liver
- painful inflammation of small pockets in the lining of your intestine (diverticulitis)
- viral infections, viral infections affecting the digestive tract
- some types of skin cancers (non-melanoma types)
- lung cancer
RARE
- blood infection (sepsis)
- lymphoma (white blood cell cancer)
- disseminated tuberculosis involving bones and other organs
- other unusual infections
- joint infections
Stop taking TOFE TABLET and inform your doctor immediately if you experience any of the following side effects:
- signs of serious infections such as fever and chills, cough, skin blisters, stomach pain, persistent headaches
- signs of ulcers or perforations in the stomach such as fever, stomach or abdominal pain, blood in the stool, unexplained changes in bowel habits
- signs of allergic reactions such as chest tightness, wheezing, severe dizziness or light-headedness, swelling of the lips, tongue or throat, hives (itching or skin rash)
- signs of blood clots in lungs or veins such as sudden shortness of breath or difficulty breathing, leg pain or tenderness, chest pain or pain in the upper back, swelling of the leg or arm, redness or discolouration in the leg or arm
- signs of a heart attack such as severe chest pain or tightness (that may spread to arms, back, jaw, neck), shortness of breath, cold sweat, light-headedness or sudden dizziness
HOW TO MANAGE SIDE EFFECTS
Nausea:
Take this medicine with or just after meals. Stick to simple meals. Avoid eating rich or spicy food. Ask for your doctor’s advice if the nausea does not improve.
Vomiting:
Drink clear or ice-cold drinks, eat bland, light foods and avoid oily, fried or sweet foods. Ask for your doctor’s advice if vomiting does not improve.
Diarrhea:
Drink a lot of fluids, such as squash, water or fruit juice to keep yourself hydrated. Do not consume any medicine by yourself without consulting your physician. Ask for your doctor’s advice if the diarrhea does not improve.
Stomach pain:
Try to rest and relax. Try to have smaller and more frequent meals and eat and drink slowly. Keep a heating pad on your stomach. Ask for your doctor’s advice if stomach pain does not improve.
Headache:
Try to take rest and avoid involving yourself in exertive activities. Apply a pain-relieving balm on your forehead. Ask for your doctor’s advice if the headache does not improve.
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